Figure 4.

Effects of SMG‐1 regulation by miR‐192 and ‐215 on motility in GC cells. (A) Effect of miR‐192 and ‐215, which target SMG‐1, on cell migration by scratch assay. (B) Effect of miR‐192 and ‐215 on cell invasion by Boyden chamber assay. Morphologic comparison of cells penetrating the artificial basement membrane is also shown. Scale bars represent 50 μm. Data represent mean ± SD. NC, nonsense control; mim, mimic; inh, inhibitor; SMG1si, SMG‐1 siRNA.