Figure 1.

(A) Patterns of progression I includes discrimination by development of new lesions only (20.6%), progression of existing metastases only (28.3%) or both new and progression of existing metastases (51.1%). (B) Pattern of progression II discriminates by progression in the central nervous system (CNS) only (20.0%), non‐CNS progression only (50.6%), and both CNS‐ and non‐CNS progression (29.4%). (C) Pattern III includes discrimination by progression of metastases that had completely disappeared at a prior staging (10.6%), and presence of controlled metastases despite progression of other lesions (76.7%).