Table 1.

Effects of rIL-15 on lymphocyte responses and toxicities in NHP.

Animal	rIL-15	Dose	Route	Frequency	Immunological Effect	Toxicity	Reference
rhesus	E. coli derived Rhesus,	10 μg/kg	S.Q.	Daily, 1×/wk for 6 weeks	Increased CD4 T cells	No adverse events	[90]
cyno	E. coli derived Rhesus,	10, 100 μg/kg	S.Q.	2×/wk for 4 weeks	Increase CD8 and CD4 Tem, NK cells	None reported	[91]
rhesus	E. coli derived Rhesus,	10 μg/kg	Not stated	Day 1,2,or day 1,3,7	Increase CD8 CD4 Tem	None reported	[41]
rhesus	E. coli derived human	20 μg/kg/day	Continuous I.V.	10 days	100× CD8 Tem 10× NK	Moderate Increase AST/ALT, neutropenia	[39]
		20–40 μg/kg	S.Q.	Daily	10× CD8 Tem 10× NK	Mild Increase AST/ALT,
rhesus	E. coli derived human	10, 20,50 μg/kg	I.V.	Daily for 12 days	4× CD8 Tcm, 6× CD8 Tem, 2.5× CD4 T cells, 6× NK cells	Neutropenia, weight loss, decrease appetite, diarrhea,	[33,40]
rhesus	Mammalian-derived human	15 μg/kg	S.Q.	Daily for 14 days	Increase CD8 and CD4 Tm, NK cells	Severe neutropenia, anemia, weight loss, rash	[34]
		2.5–10 μg/kg	S.Q.	Every 3 days for 24 days	Increase CD8 and CD4 Tm, NK cells	Well tolerated