Known side effects of methylphenidate collected as adverse reactions in ADMET 2 Behavioral

• Aggressive behavior or hostility

• Agitation

• Anxiety, nervousness, or tension

• Depressed mood

• Distractibility

• Drowsiness

• Hyperactivity

• Impaired learning

• Impulsivity

• Insomnia

• Libido changes

Cardiovascular

• Angina

• Blood pressure changes

• Cardiac arrhythmia or serious heart rhythm abnormalities

• Palpitations

• Peripheral vasculopathy (including Raynaud’s)

• Pulse changes

• Tachycardia

• Vasculitis

Gastrointestinal

• Abdominal pain

• Abnormal liver function

• Anorexia

• Decreased appetite

• Nausea

• Weight loss

Hematologic

• Anemia

• Thrombocytopenic purpura

Musculoskeletal

• Arthralgia (joint pain)

• Dyskinesia (abnormal movement)

• Muscle stiffness or aching, muscle tenderness

• Rhabdomyolysis

Neural

• Blurry vision or eyesight changes

• Dizziness

• Dry mouth

• Headache

• Numbness of fingers, toes, nose, ears, lips

• Tics (motor or verbal)

Other

• Fever

• Hair loss

• Priapism

• Serotonin Syndrome

• Skin rash, redness, or inflammation

• Urine color change or decreased output

• Urticaria