Table 3.
Cytokines and Growth Factors Altered by RT and FG-3019
| 18w Fc vs noRT | 30w Fc vs noRT | ||||
|---|---|---|---|---|---|
| Gene ID | Description | RT | RT + FG | RT | RT + FG |
| Chemokines (Chemotaxis) | |||||
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 79.8 | 4.0 | 1.1 | 0.5 |
| Ccl8 | chemokine (C-C motif) ligand 8 (MCP-2) | 29.0 | 2.0 | 5.4 | 0.9 |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 17.2 | 1.5 | 1.0 | 0.5 |
| Ccl1 | chemokine (C-C motif) ligand 1 | 8.9 | 2.1 | 2.9 | 1.2 |
| Ccl12 | chemokine (C-C motif) ligand 12 (MCP-5) | 8.3 | 0.6 | 1.9 | 0.7 |
| Ccl7 | chemokine (C-C motif) ligand 7 (MCP-3) | 7.9 | 0.6 | 1.3 | 0.5 |
| Ccl2 | chemokine (C-C motif) ligand 2 (MCP-1) | 7.3 | 0.6 | 1.1 | 0.5 |
| Ccl3 | chemokine (C-C motif) ligand 3 (MIP-1a) | 6.9 | 0.8 | 1.3 | 0.4 |
| Ccl6 | chemokine (C-C motif) ligand 6 | 5.8 | 0.7 | 2.8 | 1.1 |
| Ccl9 | chemokine (C-C motif) ligand 9 (MIP-1 g) | 5.7 | 0.8 | 2.2 | 1.0 |
| Ccl5 | chemokine (C-C motif) ligand 5 (RANTES) | 3.9 | 1.7 | 0.9 | 0.8 |
| Ccl17 | chemokine (C-C motif) ligand 17 | 3.7 | 1.1 | 0.9 | 0.7 |
| Ccl4 | chemokine (C-C motif) ligand 4 (MIP-1 p) | 3.6 | 1.4 | 0.9 | 0.6 |
| Cxcl1 | chemokine (C-X-C motif) ligand 1 | 2.4 | 0.6 | 0.7 | 0.5 |
| Cxcl16 | chemokine (C-X-C motif) ligand 16 | 2.3 | 0.7 | 1.4 | 0.9 |
| Cxcl12 | chemokine (C-X-C motif) ligand 12 (SDF-1) | 2.2 | 0.5 | 1.4 | 1.1 |
| Cxcl3 | chemokine (C-X-C motif) ligand 3 (MIP-2p) | 2.0 | 0.5 | 2.2 | 0.7 |
| Cytokines (Cell Activation) | |||||
| Tnfsf18 | tumor necrosis factor (ligand) superfamily, member 18 | 46.8 | 3.6 | 2.8 | 1.0 |
| Il1rn | interleukin 1 receptor antagonist | 5.7 | 1.2 | 1.8 | 0.7 |
| Il6 | interleukin 6 | 4.7 | 1.0 | 1.7 | 0.6 |
| Il12b | interleukin 12b | 4.7 | 1.6 | 0.9 | 0.8 |
| Tnfsf8 | tumor necrosis factor (ligand) superfamily, member 8 | 4.4 | 1.6 | 1.9 | 1.1 |
| C1qtnf9 | C1q and tumor necrosis factor related protein 9 | 3.8 | 1.7 | 2.6 | 1.2 |
| C1qtnf5 | C1q and tumor necrosis factor related protein 5 | 2.5 | 1.0 | 1.7 | 1.2 |
| Il18 | interleukin 18 | 2.4 | 0.6 | 1.6 | 1.0 |
| Il4 | interleukin 4 | 2.4 | 1.7 | 0.9 | 0.7 |
| Il12a | interleukin 12a | 0.5 | 1.1 | 0.6 | 1.4 |
| TGFβ / BMP Signaling (Differentiation, Migration, ECM Production,...) | |||||
| Gdf3 | growth differentiation factor 3 | 32.1 | 3.9 | 4.2 | 1.1 |
| Inhba | inhibin beta-A | 7.8 | 1.1 | 1.9 | 1.2 |
| Gdf6 | growth differentiation factor 6 (BMP13) | 5.9 | 0.6 | 3.7 | 1.8 |
| Fst | follistatin | 5.7 | 0.8 | 1.5 | 1.1 |
| Grem1 | gremlin 1 | 4.7 | 1.8 | 1.5 | 0.8 |
| Gdf15 | growth differentiation factor 15 | 4.0 | 1.7 | 3.0 | 2.6 |
| Fstl1 | follistatin-like 1 | 4.0 | 1.0 | 2.4 | 1.3 |
| Ltbp2 | latent transforming growth factor beta binding protein 2 | 3.9 | 1.0 | 2.1 | 1.3 |
| Ctgf | connective tissue growth factor | 3.5 | 1.1 | 1.2 | 0.8 |
| Bmp8a | bone morphogenetic protein 8a | 2.8 | 1.2 | 1.9 | 1.5 |
| Bmp6 | bone morphogenetic protein 6 | 0.2 | 0.3 | 0.4 | 0.7 |
| Wnt Signaling (Cell Polarity, Pattern Formation) | |||||
| Wnt10a | wingless related MMTV integration site 10a | 22.1 | 1.1 | 2.3 | 1.1 |
| Frzb | frizzled-related protein | 8.5 | 1.2 | 2.2 | 0.9 |
| Sfrp1 | secreted frizzled-related protein 1 | 6.3 | 0.6 | 3.2 | 1.0 |
| Wisp1 | WNT1 inducible signaling pathway protein 1 | 5.3 | 0.9 | 2.4 | 1.5 |
| Wisp2 | WNT1 inducible signaling pathway protein 2 | 4.0 | 0.9 | 2.7 | 1.3 |
| Fzd2 | frizzled homolog 2 (Drosophila) | 2.8 | 0.9 | 1.8 | 1.2 |
| Wnt7a | wingless-related MMTV integration site 7A | 2.7 | 1.2 | 1.3 | 0.9 |
| Fzd7 | frizzled homolog 7 (Drosophila) | 2.0 | 0.8 | 1.5 | 0.8 |
| IGF Signaling (Proliferation, Survival) | |||||
| Insl6 | insulin-like 6 | 7.9 | 1.4 | 3.1 | 1.2 |
| Igf1 | insulin-like growth factor 1 | 6.3 | 0.7 | 4.7 | 1.3 |
| Igfbp2 | insulin-like growth factor binding protein 2 | 3.5 | 0.8 | 1.9 | 1.6 |
| Igfbp4 | insulin-like growth factor binding protein 4 | 2.6 | 1.4 | 1.5 | 1.1 |
| Igfbp7 | insulin-like growth factor binding protein 7 | 2.5 | 0.7 | 1.5 | 1.2 |
| Igfbp6 | insulin-like growth factor binding protein 6 | 0.3 | 0.6 | 0.6 | 0.9 |
| Other Cytokines & Growth Factors | |||||
| Retnla | resistin like alpha | 10.5 | 1.7 | 6.4 | 1.4 |
| Angptl7 | angiopoietin-like 7 | 5.0 | 1.4 | 1.0 | 1.0 |
| Pdgfc | platelet-derived growth factor, C polypeptide | 4.2 | 0.4 | 1.5 | 1.0 |
| Csf3 | colony stimulating factor 3 (G-CSF) | 3.3 | 2.3 | 1.4 | 1.1 |
| Angptl3 | angiopoietin-like 3 | 3.2 | 1.2 | 1.8 | 1.3 |
| Fgf2 | fibroblast growth factor 2 | 2.5 | 1.3 | 1.4 | 0.9 |
| Pdgfd | platelet-derived growth factor, D polypeptide | 2.2 | 0.9 | 1.9 | 1.4 |
| Pgf | placental growth factor | 2.1 | 0.9 | 1.1 | 0.8 |
| Fgfbp1 | fibroblast growth factor binding protein 1 | 0.4 | 0.6 | 0.7 | 1.1 |
| Cytl1 | cytokine-like 1 | 0.3 | 1.0 | 0.4 | 0.7 |
| Retn | resistin | 0.2 | 1.2 | 0.2 | 0.3 |
Fold-change (Fc) values are relative to unirradiated (noRT) controls for RT alone and RT + FG-3019 (FG) treatment begun 16 weeks after RT