TABLE 2.

Nicotine and metabolites, as a fraction of TNE, during pregnancy and postpartum

Mean and S.D. (in parentheses, illustrating the group variation) of each metabolite as a fraction (i.e., percentage) of creatinine-corrected TNE and results from general linear repeated measures models with post hoc analyses correcting for multiple testing (Bonferroni) across the three pregnancy stages.

Fraction of Compounds	Early Pregnancy	Late Pregnancy	Postpartum	Main Effect of Time
NIC	6% (7%)*##	2% (3%)***	11% (11%)	P < 0.001
COT	10% (6%)	8% (5%)***	12% (5%)	P = 0.001
3HC	40% (12%)	43% (14%)*	37% (13%)	P = 0.026
NIC-GLUC	8% (7%)	10% (8%)**	6% (3%)	P = 0.004
COT-GLUC	20% (9%)**	24% (10%)***	17% (7%)	P < 0.001
3HC-GLUC	5% (2%)	5% (2%)	4% (2%)	P = 0.068
NNO	6% (4%)**	5% (4%)***	8% (4%)	P < 0.001
CNO	3% (1%)***	3% (1%)***	4% (1%)	P < 0.001
NNIC	0.6% (0.4%)*	0.7% (0.8%)	1% (1%)	P = 0.035
NCOT	0.2% (1%)***#	1% (2%)	1% (0.6%)	P < 0.001

^*Indicates significant differences from postpartum as P < 0.05.

^**Indicates significant differences from postpartum as P < 0.01.

^***Indicates significant differences from postpartum as P < 0.001.

^#Indicates significant differences from early to late pregnancy as P < 0.05.

^##Indicates significant differences from early to late pregnancy as P < 0.01.