Table 4.
Characteristics of volume change intervals corresponding to initiation of renal replacement therapy either with or without concurrent hypertonic saline infusion.
| Variable | RRT with HTS infusion (14 assessments) | RRT without HTS infusion (15 assessments) | P value |
|---|---|---|---|
| Change in Cerebrospinal Fluid Volume (mL) | −0.2 (−16.7 to 17.0) | −18.3 (−36.0 to −10.0) | 0.012 |
| Change in Glasgow Coma Scale Score | 0.5 (0 to 2) | −2 (−3 to 0) | 0.008 |
| Change in Serum Osmolality (mOsm/Kg) | 3 (−11 to 11) | −14 (−31 to −5) | 0.002 |
| Change in Serum Sodium (mEq/L) | 7 (−1 to 10) | 1 (−4 to 3) | 0.012 |
| Change in Serum Blood Urea Nitrogen (mg/dL) | −2 (−24 to 2) | −16 (−48 to −4) | 0.070 |
| Change in Serum Glucose (mg/dL) | −9 (−38 to 15) | −28 (−51 to −19) | 0.35 |
| Change in Serum Gap Osmoles (mOsm/L) | −6 (−11 to 2) | −4 (−9 to 3) | 0.91 |
| Change in Serum Ammonia (μg/dL) | −38 (−85 to 5) | −119 (−162 to −9) | 0.077 |
| Mean Body Temperature During Interval (°C) | 36.7 (36.4 to 37.2) | 36.7 (36.2 to 36.8) | 0.25 |
| Change in Body Temperature (°C) | −0.5 (−1.4 to 0.3) | −0.1 (−0.5 to 0.3) | 0.35 |
| Continuous renal replacement therapy, n(%) | 14 (100%) | 13 (87%) | 0.48 |
HTS=hypertonic saline, RRT=renal replacement therapy, median (interquartile range)