(a) Magnified views of two trabecular regions in the subchondral bone of a cadaver knee imaged using CMOS detectors with different pixel sizes and scintillator thicknesses. High‐resolution bone reconstruction was used. (a, top) Reconstructions of 2 × 2 binned C700 projections, mimicking the pixel size of current a‐Si:H FPDs. (a, middle) Reconstructions of C700 projections in 1 × 1 binning, showing the benefits of reduced pixel size provided by CMOS. (a, bottom) Images acquired with C400 in 1 × 1 binning, illustrating the visualization of trabecular detail using a thin scintillator. (b) A complete axial slice of C400 reconstruction obtained using high‐resolution protocol (c) A C400 reconstruction obtained using a soft‐tissue protocol with 4 × 4 pixel binning.