. 2017 Dec 1;159(2):836–852. doi: 10.1210/en.2017-00752

Table 3.

Physiological and Histological Measurements at Age 20 Weeks

	WT	Nrf2 KO	Akita	Akita Nrf2 KO
Blood glucose, mM (n = 10)	9.55 ± 0.53	11.79 ± 0.46	32.11 ± 0.51^a	32.32 ± 0.68^a
Systolic blood pressure, mm Hg (n = 10)	111.3 ± 0.71	115.9 ± 2.39	132.4 ± 2.34^a	121.4 ± 1.57^b^,^c
BW, g (n = 10)	33.08 ± 0.45	33.64 ± 0.81	23.92 ± 0.58^a	24.13 ± 0.42^a
KW, mg (n = 10)	339.5 ± 6.99	328.2 ± 9.12	540.0 ± 11.55^a	454.2 ± 10.76^a^,^d
KW/BW, mg/g (n = 10)	10.11 ± 0.26	10.02 ± 0.35	22.45 ± 0.89^a	17.73 ± 0.70^a^,^d
TL, mm (n = 10)	23.52 ± 0.65	23.3 ± 0.17	21.4 ± 0.27^b	21.91 ± 0.30^e
KW/TL, mg/mm (n = 10)	13.46 ± 0.62	13.69 ± 0.29	25.91 ± 0.84^a	20.17 ± 0.60^a^,^d
GFR/BW, mL/min/g (n = 10)	7.8 ± 0.37	9.03 ± 0.47	19.2 ± 1.56^a	18.64 ± 1.29^a
Glomerular tuft volume,^e 10³ µm³ (n = 6)	180.4 ± 4.0	179.0 ± 4.9	291.2 ± 10.28^a	237.9 ± 7.43^a^,^d
Tubular luminal area, µm² (n = 6)	52.59 ± 2.27	51.5 ± 1.86	108.59 ± 3.13^a	87.39 ± 2.3^a^,^d
RPTC volume,^e 10³ µm³ (n = 6)	7.44 ± 0.57	7.78 ± 0.29	11.64 ± 0.43^a	9.99 ± 0.34^a^,^f
ACR, µg/mg (n = 10)	22.36 ± 1.71	25.29 ± 6.09	134.1 ± 19.04^a	56.98 ± 15.88^c
Urinary Ang II/creatinine, ng/mg (n = 10)	2.57 ± 0.37	1.83 ± 0.27	23.88 ± 2.88^a	20.08 ± 3.74^a
Urinary Ang (1-7)/creatinine, ng/mg (n = 10)	3.45 ± 0.62	3.22 ± 0.58	0.91 ± 0.11^b	2.58 ± 0.39^f

Abbreviations: ACR, albumin-creatinine ratio; KW, kidney weight; TL, tibial length.

^{^a}

P < 0.001 vs WT.

^{^b}

P < 0.01 vs WT.

^{^c}

P < 0.01 vs Akita.

^{^d}

P < 0.001 vs Akita.

^{^e}

P < 0.05 vs WT.

^{^f}

P < 0.05 vs Akita.