Average lesion area in H&E-stained aortic root. Average lesion area is presented as fold change compared with C, with bars representing SEM. We found a significant relationship between average lesion area per H&E-stained aortic root sample and treatment (F = 10.92, P = 0.0002). Post hoc Tukey-corrected tests demonstrated a reduction in average lesion area for E-treated and T+E-treated mice, compared with both C- and T-treated mice. Significance compared with C, *P < 0.01. Significance compared with T, #P < 0.01.