Table 2.

Intranasal corticosteroids approved for allergic rhinitis^a

Drug	Brand name (maker)	Indications	Formulation	Dose per spray (µg)	Dosing/administration	OTC status
Beclomethasone dipropionate	Beconase AQ19 (GSK)	Rx: seasonal and perennial allergic rhinitis and nonallergic rhinitis	Aqueous suspension in metered-dose manual-pump spray; pH 5.0–6.8; contains BC (0.02%) and phenylethyl alcohol (0.25%)	42	Age ≥12 years: 1–2 sprays per nostril BID Age ≥6–12 years: 1 spray per nostril BID (up to 2 sprays per nostril BID if not responding)	Rx only
	QNASL dry nasal aerosol28 (TEVA)	Rx: seasonal and perennial allergic rhinitis	Pressurized nonaqueous solution in metered-dose aerosol device with HFA propellant; contains ethanol, no BC	80 and 40	Age ≥12 years: 2 – 80 µg sprays per nostril QD Age ≥4–11 years: 1 – 40 µg spray per nostril QD	Rx only
Budesonide	Rhinocort Aqua21 (AstraZeneca); Rhinocort Allergy29 (McNeil Consumer)	Rx: seasonal and perennial allergic rhinitis OTC: temporary relief of hay fever or other upper respiratory allergy symptoms: nasal congestion, runny nose, sneezing, and itchy nose	Aqueous suspension in metered-dose manual-pump spray; pH 4.5; contains no BC or alcohol	32	Age ≥12 years: up to 4 sprays per nostril QD Age 6–<12 years: up to 2 sprays per nostril QD	OTC
Ciclesonide	Omnaris nasal spray30 (Sunovion) Zetonna nasal aerosol31 (Sunovion)	Rx: nasal symptoms associated with seasonal allergic rhinitis in adults and children aged ≥6 years and perennial allergic rhinitis in adults and adolescents aged ≥12 years Rx: Seasonal and perennial allergic rhinitis	Hypotonic aqueous suspension in metered-dose, manual pump spray; pH 4.5; contains no BC or alcohol Pressurized, metered-dose aerosol canister and actuator containing a solution of ciclesonide in HFA propellant and ethanol; no BC	50 37	Age ≥6 years: 2 sprays per nostril QD Age ≥12 years: 1 spray per nostril QD	Rx only Rx only
Flunisolide	Various	Rx: nasal treatment of the symptoms of seasonal or perennial rhinitis	Solution in spray bottle; pH 5.3; contains BC; no alcohol	25	Age 6–14 years: 1 spray per nostril TID or 2 sprays per nostril BID Age >14 years: 2 sprays per nostril BID/TID	Rx only
Fluticasone furoate	Veramyst32 (GSK) Flonase Sensimist Allergy Relief52 (GSK Consumer Healthcare)	Rx: seasonal and perennial allergic rhinitis OTC: temporary relief of symptoms due to hay fever or other upper respiratory allergies in children aged ≥2 years and adults: nasal congestion; runny nose; sneezing; itchy nose; and itchy, watery eyes for ages ≥12 years	Aqueous suspension in metering, atomizing spray pump; pH 6; contains BC (0.015%); no alcohol	27.5	Age 2–11 years: 1 spray per nostril QD Age ≥12 years: 2 sprays per nostril QD	OTCb
Fluticasone propionate	Flixonase22 (GSK) Flonase Allergy Relief50 (GSK Consumer Healthcare)	Rx: seasonal and perennial allergic rhinitis, nasal polyps OTC: temporary relief of hay fever or other upper respiratory allergy symptoms: nasal congestion; runny nose; sneezing; itchy nose; itchy, watery eyes	Aqueous suspension in metering, atomizing spray pump; pH 5–7; contains BC (0.02%) and phenylethyl alcohol (0.25%)	50	Age 4–11 years: 1 spray per nostril QD Age ≥12 years: 2 sprays per nostril QD	OTC
Mometasone furoate	Nasonex20 (Merck Sharp & Dohme)	Rx: seasonal and perennial allergic rhinitis, nasal polyps, prophylaxis of seasonal allergic rhinitis OTC: treatment of allergic rhinitis (scope of indication varies by country)	Aqueous suspension in metered-dose, manual pump spray; pH 4.3–4.9; contains BC; no alcohol	50	Age 2–11 years: 1 spray per nostril QD Age ≥12 years: 2 sprays per nostril QD	OTC (outside the USA)
Triamcinolone acetonide	Nasacort23 (Sanofi) Nasacort Allergy 24HR33 (Chattem, Inc., a Sanofi Company)	Rx: seasonal and perennial allergic rhinitis OTC: temporary relief of hay fever or other upper respiratory allergy symptoms: nasal congestion; runny nose; sneezing; itchy nose	Aqueous suspension in metered-dose pump spray; pH 4.5–6.0; contains BC; no alcohol	55	Age 2–5 years: 1 spray per nostril QD Age 6–11 years: 1 spray per nostril QD Age ≥12 years: 2 sprays per nostril QD/BID	OTC

Notes:

^aIndications, dosage, and prescription status may vary by country.

^bApproved by US Food and Drug Administration for OTC use as of August 2016; OTC product is anticipated to be available commercially in 2017.

Abbreviations: BC, benzalkonium chloride; BID, twice daily; HFA, hydrofluoroalkane; OTC, over-the-counter; QD, once daily; Rx, prescription; TID, three times daily.