Table 5.
Predictors of potential drug–drug interactions in chronic kidney disease (CKD) patients
| Variables | Patients (n=209)
|
Univariate
|
Multivariate
|
|||
|---|---|---|---|---|---|---|
| Interaction present, n (%) | Interaction absent, n (%) | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| Gender | ||||||
| Male | 104 (81.9) | 23 (18.1) | 1.65 (0.9–3.2) | 0.136 | – | – |
| Female | 60 (73.2) | 22 (26.8) | ||||
| Age (years) | ||||||
| <60 | 150 (80.2) | 37(19.8) | 0.4 (0.2–0.9) | 0.012 | 0.3 (0.1–0.8) | 0.019 |
| ≥60 | 14 (63.6) | 8 (36.4) | ||||
| Hospital stay (days) | ||||||
| <5 | 48 (65.8) | 25 (34.2) | 3.0 (1.5–5.9) | 0.001 | 2.4 (1.1–5.0) | 0.024 |
| ≥5 | 116 (85.3) | 20 (14.7) | ||||
| Number of drugs | ||||||
| <5 | 23 (50.0) | 23 (50.0) | 6.4 (3.1–13.3) | <0.001 | 6.8 (3.1–15.1) | <0.001 |
| ≥5 | 141 (86.5) | 22 (13.5) | ||||
| CKD stage | ||||||
| 1–3 | 15 (65.2) | 8 (34.8) | 0.5 (0.2–1.2) | 0.107 | – | – |
| 4–5 | 149 (81.0) | 37 (19.9) | ||||
| Diabetes | ||||||
| Yes | 33 (86.8) | 5 (13.2) | 2.0 (0.7–5.5) | 0.172 | – | – |
| No | 131 (76.6) | 40 (23.4) | ||||
| Hypertension | ||||||
| Yes | 121 (82.9) | 25 (17.1) | 2.3 (1.1–4.5) | 0.020 | 3.0 (1.2–7.5) | 0.017 |
| No | 43 (68.3) | 20 (31.7) | ||||
Notes: Hosmer–Lemeshow goodness-of-fit test: p=0.65. Data in bold indicates statistical significance (P-value<0.05) obtained after statistical analysis.
Abbreviations: OR, odds ratio; CI, confidence interval.