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MSP analysis of histone H3K27me3 methylation status. Amplification and detection were performed by MSP. The H3K27me3 gene was shown to be methylated in primary CLL cells. However, co-culture with HESS-5 cells led to demethylation of this gene in CLL cells. The data shown are representative of three independent experiments (*P<0.05 vs. U266 cells). MSP, methylation-specific PCR; ß2-MG, ß2-microglobulin; CLL, chronic lymphocytic leukemia.
