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. 2017 Nov 22;15(2):1330–1338. doi: 10.3892/etm.2017.5539

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Copyright: © An et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — HMGB1 dynamic change and JAK2/STAT3 phosphorylation after SAH. (A) The levels of phosphorylated JAK2 and STAT3 relative to β-actin were significantly increased at 6 h, 1 day and 3 days after SAH compared with the Sham group. (B) No significant increase of total HMGB1 expression was observed at 6 h after SAH; however, a significant increase was demonstrated at day 1 compared with the Sham group. The level then decreased to the baseline level at day 3. (C) Cytoplasmic HMGB1 level significantly increased at 6 h and 1 day after SAH compared with the Sham group; however, the level decreased at day 3. (D) Nuclear HMGB1 significantly decreased at 6 h after SAH compared with the Sham group; however, this level increased at day 1 and day 3 compared with the Sham group. β-actin and LMNB1 were used as internal references. Data are presented as the mean ± standard deviation. *P<0.05 vs. the Sham group. HMGB1, high mobility group box 1; JAK2/STAT3, Janus kinase 2/signal transducer and activator of transcription 3; SAH, subarachnoid hemorrhage; SAH 6 h, 6 h after SAH induction; SAH 1 d, 1 day after SAH induction; SAH 3 d, 3 days after SAH induction; p, phosphorylated; LMNB1, Lamin B1.