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. 2017 Nov 22;15(2):1330–1338. doi: 10.3892/etm.2017.5539

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Copyright: © An et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Regulatory effects of AG490. (A) AG490 significantly inhibited JAK2/STAT3 phosphorylation after SAH compared with the SAH and SAH + DMSO groups. (B) Total, (C) cytoplasmic and (D) nuclear HMGB1 expression was inhibited by AG490 administration following SAH compared with the SAH and SAH + DMSO groups. β-actin and LMNB1 were used as internal references. Data are presented as the mean ± standard deviation. *P<0.05 vs. the Sham group; ^#P<0.05 vs. the SAH and SAH + DMSO groups. JAK2/STAT3, Janus kinase 2/signal transducer and activator of transcription 3; SAH, subarachnoid hemorrhage; DMSO, dimethyl sulfoxide; LMNB1, Lamin B1.