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Mechanism of action of lifitegrast.
Notes: Lifitegrast blocks ICAM-1 and LFA-1 interaction, which is critical in migration of DCs to lymph nodes, naïve T cell activation by DCs, and T cell transmigration into the ocular surface.
Abbreviations: APCs, antigen-presenting cells; DC, dendritic cell; ICAM-1, intercellular adhesion molecule; LFA-1, lymphocyte functional associated antigen-1.
