Table 2.

Structures of protein receptors (PDB ID) for docking simulation

No	Pathology of cancer cells	Drug target mechanisma	PDB ID
1	Avoiding immune destruction	Anti CTLA-4 monoclonal antibody	4GCA
2	Replicative immortality	Telomerase inhibitor	5DFM
3	Tumor-promoting inflammation	Selective anti-inflammatory drugs	1CX2
4	Invasion and metastasis	Hepatocyte growth factor/c-Met inhibitor	4MXC
5	Angiogenesis	VEGFR signaling inhibitor	3CP9
6	Genome instability	PARP inhibitor	5WRQ
7	Resisting cell death	Pro-apoptotic BH3 mimetic (inhibitor BCl-2)	4C5D
8	Deregulating cell energetics	Aerobic glycolysis inhibitor	4JNK
9	Sustaining proliferative signaling	EGFR inhibitor	1M17
10	Evading growth suppressors	CDK2 inhibitor	2UZO
		CDK6 inhibitor	5L2I

Note:

^aThe 10-drug target mechanisms were selected according to the hallmarks of cancer, as described by Hanahan and Weinberg.26

Abbreviation: PDB ID, Protein Data Bank identity.