Table 7.

The newly designed xanthone derivatives and their predicted cytotoxic activities calculated by using the best QSAR model

Compound	R1	R2	IC50 (µg/mL)	IC50 (µM)
11	OH	H	0.013	0.049
12	OCH3	H	0.016	0.058
13	NH2	H	1.662	6.413
14	N(CH3)2	H	0.276	0.960
15	H	SH	0.038	0.136
16	SH	SH	0.091	0.299
17	NH2	SH	0.134	0.460
18	OCHCH2	H	0.100	0.349
19	OCH2CH2CH3	H	0.029	0.095
20	C(CH3)3	H	3.586	11.940
21	OCOCH3	H	0.011	0.035
22	NHCOCH3	H	0.006	0.021
23	N(C(CH3)3)2	H	5.498	14.188
24	CHC=C(CH3)2	H	5.404	18.117
25	C(CH2CH3)3	H	0.705	2.059

Abbreviations: IC₅₀, inhibitory concentration 50%; QSAR, quantitative structure–activity relationship.