Table 1.

Pharmacokinetic parameters after 8 h of intravenous administration of mitomycin C or mitomycin C-loaded pH-sensitive liposomes to rats at a dose of 5 mg/kg

PK parameters	Solution	pH-sensitive liposomes
AUC0–∞ (µg·h/L)	10.07±0.31	18.82±0.51*
t1/2α (h)	0.10±0.04	0.08±0.02
t1/2β (h)	1.35±0.15	1.60±0.04*
Cl (L/h/kg)	0.10±0.03	0.05±0.01*
MRT (h)	1.53±0.16	2.21±0.05*
Vss (L/kg)	0.13±0.01	0.12±0.01

Notes: Data are presented as mean ± standard deviation (n=3).

^*p<0.05 was considered statistically significant.

Abbreviations: PK, pharmacokinetic; AUC_0–∞, area under the concentration–time curve; t_1/2α, half-life of the distribution phase; t_1/2β, half-life of the elimination phase; Cl, clearance; MRT, mean residence time; V_ss, volume of distribution at a steady state.