Table 2.
Complete blood counts after 7 days of administration of a mitomycin C solution or mitomycin C-loaded pH-sensitive liposomes to rats at a dose of 5 mg/kg
| Assay | Blank | Solution | pH-sensitive liposomes | Reference values |
|---|---|---|---|---|
| White blood cells (×103/mm3) | 6.2±2.4 | 4±0.7 | 4.6±0.2 | 6–17 |
| Lymphocyte (%) | 58.8±15.6 | 70±6.2 | 53.1±19.6 | 65–85 |
| Hemoglobin (mg/dL) | 16.1±1.7 | 15.45±1.1 | 12.4±1.6 | 11–18 |
| Hematocrit (%) | 43.8±4.5 | 43.45±2.6 | 34.3±5.5 | 36–48 |
| Red blood cells (×106/mm3) | 7.71±1.14 | 7.36±0.8 | 5.67±0.97 | 7–10 |
| Platelets (×103/mm3) | 690±174 | 356±144.2* | 645±295 | 500–1,300 |
| Blood urea nitrogen (mg/dL) | 16.3±0.3 | 24.2±3.7* | 14.1±1.9 | 15–21 |
| Creatinine (mg/dL) | 0.1±0.1 | 0.25±0.2 | 0.2±0.1 | 0.2–0.8 |
| Aspartate aminotransferase (IU/L) | 127±10 | 203.5±17.7* | 114±25 | 63–175 |
| Alanine aminotransferase (IU/L) | 24±0 | 21.5±3.5 | 20±3 | 20–92 |
Notes: Data are presented as mean ± standard deviation (n=3).
*
p<0.05 was considered statistically significant.