Table S2.
Individual effect of baseline TBiL concentrations and cigarette smoking on primary and secondary outcomes
| Outcomes | Events/N (%) | OR (95% CI)
|
|
|---|---|---|---|
| Unadjusted | Adjusteda | ||
| Progression of CKD | |||
| TBiL (μmol/L) | |||
| Tertiles | |||
| T1 (<8.7) | 109/4210 (2.6) | Ref (1.00) | Ref (1.00) |
| T2 (8.7<11.7) | 102/4197 (2.4) | 0.94 (0.71–1.23) | 0.96 (0.72–1.28) |
| T3 (≥11.7) | 83/4223 (2.0) | 0.75 (0.56–1.01) | 0.71 (0.51–0.97) |
| Smoking status | |||
| Never | 194/8972 (2.2) | Ref (1.00) | Ref (1.00) |
| Former | 24/926 (2.6) | 1.20 (0.78–1.85) | 0.93 (0.56–1.56) |
| Current | 76/2731 (2.8) | 1.30 (0.99–1.69) | 1.18 (0.81–1.71) |
| Rapid decline in eGFR | |||
| TBiL (μmol/L) | |||
| Tertiles | |||
| T1 (<8.7) | 307/4209 (7.3) | Ref (1.00) | Ref (1.00) |
| T2 (8.7<11.7) | 270/4197 (6.4) | 0.87 (0.74–1.04) | 0.94 (0.79–1.12) |
| T3 (≥11.7) | 226/4226 (5.3) | 0.72 (0.60–0.86) | 0.78 (0.64–0.94) |
| Smoking status | |||
| Never | 559/8971 (6.2) | Ref (1.00) | Ref (1.00) |
| Former | 58/926 (6.3) | 1.01 (0.76–1.33) | 1.15 (0.82–1.61) |
| Current | 185/2731 (6.8) | 1.09 (0.92–1.30) | 1.34 (1.04–1.71) |
| Decline in eGFR, % per year | |||
| TBiL (μmol/L) | |||
| Tertiles | |||
| T1 (<8.7) | 1.57 (3.45)b | Ref (0.00) | Ref (0.00) |
| T2 (8.7<11.7) | 1.37 (3.31)b | −0.19 (−0.34, −0.05)c | −0.08 (−0.22, 0.06)c |
| T3 (≥11.7) | 1.16 (3.37)b | −0.40 (−0.55, −0.26)c | −0.25 (−0.40, −0.11)c |
| Smoking status | |||
| Never | 1.35 (3.33)b | Ref (0.00) | Ref (0.00) |
| Former | 1.42 (3.34)b | 0.06 (−0.16, 0.29)c | 0.14 (−0.12, 0.40)c |
| Current | 1.39 (3.54)b | 0.04 (−0.11, 0.18)c | 0.17 (−0.03, 0.36)c |
Notes:
a
Adjusted for age, sex, treatment group, systolic blood pressure, body mass index, smoking status, alcohol intake, eGFR, proteinuria, serum glucose, total cholesterol, alanine aminotransferase, aspartate transaminase at baseline, and time-averaged systolic blood pressure during treatment if not as an independent variable.
b
Mean (SD).
c
Values are regression coefficients (95% CI).
Abbreviations: TBiL, total bilirubin; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference; T1, tertile 1; T2, tertile 2; T3, tertile 3.