Table S3.
Individual effect of baseline DBiL concentrations on primary and secondary outcomes
| Outcomes | Events/N (%) | OR (95% CI)
|
|
|---|---|---|---|
| Unadjusted | |||
| Progression of CKD | |||
| DBiL (μmol/L) | |||
| Per SD | 0.84 (0.74–0.95) | 0.78 (0.68–0.90) | |
| Tertiles | |||
| T1 (<1.5) | 105/4052 (2.6) | Ref (1.00) | Ref (1.00) |
| T2 (1.5<2.1) | 109/4365 (2.5) | 0.96 (0.73–1.26) | 0.91 (0.68–1.22) |
| T3 (≥2.1) | 80/4216 (1.9) | 0.73 (0.54–0.98) | 0.67 (0.48–0.93) |
| Categories | |||
| T1–T2 | 214/8417 (2.5) | Ref (1.00) | Ref (1.00) |
| T3 | 80/4216 (1.9) | 0.74 (0.57–0.96) | 0.70 (0.53–0.93) |
| Rapid decline in eGFR | |||
| DBiL (μmol/L) | |||
| Per SD | 0.84 (0.78–0.91) | 0.85 (0.78–0.92) | |
| Tertiles | |||
| T1 (<1.5) | 293/4051 (7.2) | Ref (1.00) | Ref (1.00) |
| T2 (1.5<2.1) | 283/4365 (6.5) | 0.89 (0.75–1.05) | 0.95 (0.79–1.13) |
| T3 (≥2.1) | 227/4216 (5.4) | 0.73 (0.61–0.87) | 0.78 (0.64–0.95) |
| Categories | |||
| T1–T2 | 576/8416 (6.8) | Ref (1.00) | Ref (1.00) |
| T3 | 227/4216 (5.4) | 0.77 (0.66–0.91) | 0.81 (0.68–0.96) |
| Decline in eGFR, % per year | |||
| DBiL (μmol/L) | |||
| Per SD | −0.16 (−0.22, −0.10)c | −0.17 (−0.23, −0.11)c | |
| Tertiles | |||
| T1 (<1.5) | 1.52 (3.49)b | Ref (0.00) | Ref (0.00) |
| T2 (1.5<2.1) | 1.41 (3.35)b | −0.11 (−0.25, 0.04)c | −0.03 (−0.18, 0.11)c |
| T3 (≥2.1) | 1.17 (3.29)b | −0.35 (−0.49, −0.20)c | −0.31 (−0.46, −0.16)c |
| Categories | |||
| T1–T2 | 1.46 (3.42)b | Ref (0.00) | Ref (0.00) |
| T3 | 1.17 (3.29)b | −0.29 (−0.42, −0.17)c | −0.29 (−0.42, −0.16)c |
Notes:
a
Adjusted for age, sex, treatment group, systolic blood pressure, body mass index, smoking status, alcohol intake, eGFR, proteinuria, serum glucose, total cholesterol, alanine aminotransferase, aspartate transaminase at baseline, and time-averaged systolic blood pressure during treatment.
b
Mean (SD).
c
Values are regression coefficients (95% CI).
Abbreviations: DBiL, direct bilirubin; SD, standard deviation; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference; T1, tertile 1; T2, tertile 2; T3, tertile 3.