Table 10.

Summary of results of dependence (psychological dependence, physical dependence, tolerance) assessment (13 weeks–1 year)

Assessment timing	Questions	Patients (n)	Remarkable	Moderate	Slight	None	Unknown	Remarkable or moderate	Slight or none
On-treatment (1 year after the initial dose)	Do you feel clearheaded on this drug?	2,306	0	1	41	2,264	0	1	2,305
	Do you feel indifferent to disliked persons or things on this drug?	2,317	1	5	24	2,287	0	6	2,311
	Do you become hyperactive or talkative on this drug?	2,317	0	2	20	2,295	0	2	2,315
	Do you become broad-minded on this drug?	2,317	0	1	18	2,298	0	1	2,316
	Do you feel intoxicated on this drug?	2,317	1	1	25	2,290	0	2	2,315
	Do you feel irritable or somewhat lonely when the drug effect runs out?	2,318	0	1	34	2,283	0	1	2,317
	Do you want to continue taking this drug?	2,318	82	171	508	1,557	0	253	2,065
	Do you think this drug became less effective?	2,317	5	21	166	2,125	0	26	2,291
	Do you want to take this drug in larger doses?	2,317	3	5	85	2,224	0	8	2,309
	Do you feel nauseated or tremulous when the drug effect runs out?	2,317	0	0	9	2,308	0	0	2,317
Off-treatment (4 weeks after the end [or interruption] of the treatment)	Have you felt irritable or unstable after you were off this drug?	257	0	0	3	254	0	0	257
	Have you had more difficulty in sleeping after you were off this drug?	257	0	1	2	254	0	1	256
	Have you had nausea, vomiting, tremors of limb or perspiration after you were off this drug?	256	0	0	0	256	0	0	256
	Do you really want to take this drug again?	257	0	6	18	233	0	6	251
	Have you had convulsions after you were off this drug?	257	0	0	0	257	0	0	257
	Have you had clouded mind or heard or seen anything unusual after you were off this drug?	257	0	0	1	256	0	0	257