Table 8.

Assessment of serum prolactin and thyroid hormones before and after the treatment onset

Test item (unit)	Patients (n)	Assessment timing	Mean	SD	Min	Median	Max	One-sample t-test
Prolactin (ng/mL)	53	1 month or shorter before the initial dose	47.04	147.95	4.00	18.90	1,083.79	p=0.323
		After the initial dose (latest measurement)	59.14	231.74	5.23	19.40	1,705.57
		Change from the pretreatment measurement	12.10	88.22	−135.77	0.90	621.78
TSH (μIU/mL)	132	1 month or shorter before the initial dose	2.39	2.37	0.00	1.70	13.80	p=0.035*
		After the initial dose (latest measurement)	2.00	1.90	0.00	1.63	11.30
		Change from the pretreatment measurement	−0.39	2.12	−12.00	−0.01	6.07
FT3 (pg/mL)	104	1 month or shorter before the initial dose	2.13	0.49	0.70	2.15	4.12	p=0.513
		After the initial dose (latest measurement)	2.10	0.59	0.80	2.00	4.80
		Change from the pretreatment measurement	−0.03	0.41	−1.00	0.00	2.30
FT4 (ng/dL)	124	1 month or shorter before the initial dose	1.01	0.25	0.58	1.00	2.07	p=0.505
		After the initial dose (latest measurement)	1.02	0.25	0.53	1.00	1.93
		Change from the pretreatment measurement	0.01	0.19	−0.41	0.00	0.88

Notes: The difference between the measurements at 1 month or shorter before the initial dose and the latest measurement after the initial dose.

^*p<0.05; significance was tested by one-sample t-test.

Abbreviations: FT3, free triiodothyronine; FT4, free thyroxine; max, maximum; min, minimum; TSH, thyroid-stimulating hormone.