Table 9.

Summary of results of dependence (psychological dependence, physical dependence, tolerance) assessment (up to 12 weeks)

Assessment timing	Questions	Patients (n)	Remarkable	Moderate	Slight	None	Unknown	Remarkable or moderate	Slight or none
On-treatment (12 weeks after the initial dose)	Do you feel clearheaded on this drug?	3,252	0	3	84	3,164	1	3	3,248
	Do you feel indifferent to disliked persons or things on this drug?	3,262	1	6	62	3,192	1	7	3,254
	Do you become hyperactive or talkative on this drug?	3,261	1	3	45	3,211	1	4	3,256
	Do you become broad-minded on this drug?	3,262	0	3	37	3,221	1	3	3,258
	Do you feel intoxicated on this drug?	3,261	2	3	75	3,180	1	5	3,255
	Do you feel irritable or somewhat lonely when the drug effect runs out?	3,260	1	3	51	3,204	1	4	3,255
	Do you want to continue taking this drug?	3,261	119	317	708	2,115	2	436	2,823
	Do you think this drug became less effective?	3,260	6	34	280	2,938	2	40	3,218
	Do you want to take this drug in larger doses?	3,261	2	26	191	3,042	0	28	3,233
	Do you feel nauseated or tremulous when the drug effect runs out?	3,261	1	0	25	3,235	0	1	3,260
Off-treatment (4 weeks after the end [or interruption] of the treatment)	Have you felt irritable or unstable after you were off this drug?	530	2	0	3	525	0	2	528
	Have you had more difficulty in sleeping after you were off this drug?	530	2	1	8	519	0	3	527
	Have you had nausea, vomiting, tremors of limb, or perspiration after you were off this drug?	530	0	0	3	527	0	0	530
	Do you really want to take this drug again?	530	1	4	39	486	0	5	525
	Have you had convulsions after you were off this drug?	530	0	0	0	530	0	0	530
	Have you had clouded mind or heard or seen anything unusual after you were off this drug?	530	0	0	1	529	0	0	530