Figure 4.

Effects of mosapride on TJ protection ultrastructure detected by transmission electron microscopy. (A) TJ structures were intact in the control group. (B) Aspirin severely disrupted the TJ ultrastructure, characterized by decreased electron-dense materials in the TJ and loss of TJ membrane fusion, further widened gaps and tracer extravasation. Pretreatment with (C) 0.4, (D) 0.5 or (E) 0.6 mg/kg mosapride markedly alleviated the effects of aspirin. White arrowheads indicate typical changes in TJ structure, including widened gaps and tracer extravasation. Scale bar, 0.5 µm. TJ, tight junction.