Table 3. Analysis of Currents Recorded in Inside-Out Configuration from Wild-Type and Mutant KAT1 Channels.
| 0 min |
5 min |
7 min |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| V1/2 |
S |
n |
V1/2 |
S |
n |
V1/2 |
S |
n |
|
| KAT1 WT | ND | ND | 3 | ND | ND | 3 | ND | ND | 3 |
| KAT1 S676D | −156.3 ± 1.5 mV | 13.2 ± 1.4 | 3 | −155.2 ± 1.7 mV | 17.3 ± 1.4 | 3 | −158.2 ± 1.7 mV | 19.7 ± 1.5 | 3 |
| KAT1 WT + FC | −157.5 ± 1.2 mV | 16.2 ± 1.4 | 3 | −159 ± 1.6 mV | 22 ± 1.4 | 3 | −156 ± 2 mV | 22.3 ± 1.8 | 3 |
The 0, 5, and 7 min indicate time after patch excision. V1/2, half activation potential; S, inverse slope coefficient; n, number of cells; WT, wild type.