Table 1.
Baseline Demographic Characteristics According to Aβ Status
| Characteristic | Study Groupa | P Value | ||
|---|---|---|---|---|
| All (n = 133) | Aβ Negative (n = 94) | Aβ Positive (n = 39)b | ||
| Age, y | 75.9 (7.0) | 74.9 (7.2) | 78.4 (5.7) | .003 |
| Educational attainment, y | 15.8 (3.0) | 15.8 (3.1) | 15.7 (2.9) | .94 |
| Female, No. (%) | 75 (56.4) | 54 (57.4) | 21 (53.8) | .85 |
| SCD compositec | 0.01 (0.8) | −0.09 (0.7) | 0.11 (0.9) | .15 |
| GDSd | 3.33 (2.8) | 3.31 (2.8) | 3.38 (2.9) | .90 |
| Aβ FLR DVR (PVC) | 1.42 (0.4) | 1.18 (0.1) | 2.00 (0.4) | <.001 |
| EC FTP-PET SUVR (PVC) | 1.33 (0.3) | 1.22 (0.2) | 1.43 (0.4) | <.001 |
| IT FTP-PET SUVR (PVC) | 1.45 (0.2) | 1.41 (0.1) | 1.48 (0.2) | .02 |
| High Aβ burden, No. (%) | 39 (29.3) | NA | NA | NA |
| APOEε4 carrier, No. (%) | 35 (26.3) | 14 (14.9) | 23 (59.0) | <.001 |
Abbreviations: Aβ, β-amyloid; APOEε4, apolipoprotein E ε4 allele; DVR, distribution volume ratio; EC, entorhinal cortex; FLR, frontal, lateral, and retrosplenial tracer; FTP, flortaucipir F 18; GDS, Geriatric Depression Score; IT, inferior temporal cortex; NA, not applicable; PVC, partial volume correction; SCD, subjective cognitive decline; SUVR, standardized uptake value ratio.
Unless otherwise indicated, data are expressed as mean (SD).
Indicates cutoff of Pittsburgh compound B PVC DVR FLR of greater than 1.34 using gaussian mixture modeling Aβ.
Calculated as the mean z-transformed subscales from the Memory Functioning Questionnaire,22 the Everyday Cognition battery,23 and a 7-item questionnaire adapted from the Structured Telephone Interview for Dementia Assessment. Scores represent a z-score composite ranging from −1.15 to 2.81, with higher scores indicating greater subjective concern.
Scores range from 0 to 11, with higher scores indicating greater development of depression.