Table 2.

Regression Coefficients Estimating SCD From EC and IT Tau and Covariates^a

Covariate by Model (R2 Value)	β (95% CI)	P Value	Bootstrapped P Valueb	Relative Importance (% Explained of R2 Value)c
Model 2a (0.24)
EC tau	0.35 (0.19 to 0.52)	<.001	<.001	47
Age	0.06 (−0.11 to 0.23)	.49	.36	11
Male	0.11 (−0.04 to 0.27)	.15	.69	4
Educational attainment	−0.06 (−0.21 to 0.10)	.48	.59	0
Adjusted GDS score	0.30 (0.14 to 0.45)	<.002	<.001	36
Time from NP to FTP-PET	0.05 (−0.10 to 0.20)	.53	.53	0
Model 2b (0.14)
IT tau	0.10 (−0.08 to 0.28)	.27	.32	10
Age	0.14 (−0.04 to 0.32)	.13	.10	25
Male	0.08 (−0.08 to 0.25)	.34	.42	5
Educational attainment	−0.02 (−0.19 to 0.14)	.79	.91	0
Adjusted GDS	0.28 (0.11 to 0.44)	.001	<.001	58
Time from NP to FTP-PET	0.05 (−0.11 to 0.22)	.53	.53	1
Model 3 (0.18)
Aβ FLR	0.24 (0.08 to 0.40)	.005	.005	29
Age	0.13 (−0.04 to 0.30)	.13	.11	19
Male	0.08 (0.14 to 0.46)	.31	.39	4
Educational attainment	−0.03 (−0.20 to 0.13)	.67	.77	0
Adjusted GDS	0.30 (0.14 to 0.46)	<.001	<.001	47
Time from NP to FTP-PET	0.05 (−0.11 to 0.21)	.56	.56	0
Post hoc EC tau and IT tau model (0.25)
EC tau	0.45 (0.24 to 0.65)	<.001	<.001	45
IT tau	−0.16 (−0.37 to 0.04)	.12	.03	6
Age	0.09 (−0.08 to 0.27)	.29	.18	10
Male	0.10 (−0.05 to 0.26)	.20	.40	4
Educational attainment	−0.04 (−0.20 to 0.12)	.61	.87	0
Adjusted GDS	0.29 (0.14 to 0.45)	<.001	<.001	33
Time from NP to FTP-PET	0.04 (−0.11 to 0.20)	.59	.59	0
Model 4a (0.25)
EC tau	0.36 (0.15 to 0.58)	.001	<.001	35
Age	0.04 (−0.13 to 0.21)	.66	.58	8
Male	0.10 (−0.05 to 0.26)	.20	.09	4
Educational attainment	−0.06 (−0.21 to 0.10)	.48	.54	0
Adjusted GDS	0.30 (0.14 to 0.46)	<.01	<.001	35
Aβ FLR	0.13 (−0.06 to 0.33)	.18	0.05	11
EC tau × Aβ FLR	−0.36 (−0.34 to 0.09)	.25	.18	4
Time from NP to FTP-PET	0.03 (−0.12 to 0.19)	.67	.67	0
Model 4b (0.19)
IT tau	−0.14 (−0.76 to 0.47)	.65	.79	5
Age	0.14 (−0.05 to 0.32)	.15	.11	16
Male	0.08 (−0.08 to 0.25)	.31	.53	4
Educational attainment	−0.04 (−0.20 to 0.13)	.66	.78	0
Adjusted GDS	0.30 (0.14 to 0.46)	<.001	<.001	48
Aβ FLR	0.22 (0.03 to 0.41)	.03	.02	25
IT tau × Aβ FLR	0.16 (−0.47 to 0.79)	.61	.64	0
Time from NP to FTP-PET	0.05 (−0.11 to 0.21)	.53	.53	0

Abbreviations: Aβ, β-amyloid; APOEε4, apolipoprotein E ε4 allele; DVR, distribution volume ratio; EC, entorhinal cortex; FLR, frontal, lateral, and retrosplenial; FTP-PET, flortaucipir F 18 positron emission tomography; GDS, Geriatric Depression Score; IT, inferior temporal cortex; NA, not applicable; NP, neuropsychological testing; PVC, partial volume correction; SCD, subjective cognitive decline; SUVR, standardized uptake value ratios.

^aAll variables are centered. Models are described in the Statistical Analysis subsection of the Methods section.

^bNonparametric local linear kernel-based estimation using independently identically distributed draw bootstrapping (time from NP not included in model).

^cRelative importance using the metric of Lindemann et al.³⁴