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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Semin Immunol. 2017 Oct 9;34:78–102. doi: 10.1016/j.smim.2017.09.007

Figure 6. Main strategies for nanotechnology-based anti-inflammatory treatment of autoimmune diseases.

Figure 6

There are four approaches of nanotechnology-based treatments depending on their cargo. First, the delivery of small immunomodulatory molecules has been extensively explored in the suppression of the inflammatory activity of macrophages and dendritic cells (DCs). Second, the delivery of anti-inflammatory peptides has been used in different pathologies. Finally, gene therapy strategies include: pDNA delivery for the expression of anti-inflammatory cytokines, and siRNA or antisense oligonucleotide (AONs) delivery for the downregulation of pro-inflammatory molecules expression.