Table 2B.
Ligand | Nanosystem | Key results | Ref. |
---|---|---|---|
Ab for CD40, CD11c, DEC-205 | PEG-PLGA NPs | Only active targeting improved CD8+ T cell activation in vitro and in vivo | [105] |
Mannosylation | PLGA NPs | More efficient in vitro uptake of NPs by DCs with chemically conjugated mannan than for plain mannan-adsorbed NPs | [106] |
PLGA NPs | Mannose functionalization stimulated Th1 bias responses, decreasing tumor growth, both in prophylactic and therapeutic treatments | [107] |
Ab: antibody; NP: nanoparticle; PEG-PLGA: pegylated poly(lactic-co-glycolic) acid; PLGA: poly(lactic-co-glycolic) acid; Th1: T helper 1