. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Semin Immunol. 2017 Oct 9;34:78–102. doi: 10.1016/j.smim.2017.09.007

Table 2B.

Summary of the different strategies adopted for the active targeting to dendritic cells

Ligand	Nanosystem	Key results	Ref.
Ab for CD40, CD11c, DEC-205	PEG-PLGA NPs	Only active targeting improved CD8⁺ T cell activation in vitro and in vivo	[105]
Mannosylation	PLGA NPs	More efficient in vitro uptake of NPs by DCs with chemically conjugated mannan than for plain mannan-adsorbed NPs	[106]
Mannosylation	PLGA NPs	Mannose functionalization stimulated Th1 bias responses, decreasing tumor growth, both in prophylactic and therapeutic treatments	[107]

Ab: antibody; NP: nanoparticle; PEG-PLGA: pegylated poly(lactic-co-glycolic) acid; PLGA: poly(lactic-co-glycolic) acid; Th1: T helper 1