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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Neurobiol Aging. 2017 Aug 18;60:92–103. doi: 10.1016/j.neurobiolaging.2017.08.010

Figure 4. ADORA2A rs9608282 is associated with larger hippocampal volume in amyloid-positive participants (classified by PET scan and/or CSF-amyloid beta level).

Figure 4

For statistical analysis, each participant was classified by their amyloid status (positive versus negative) at the baseline visit (determined by standard cutoffs on [18F]Florbetapir PET scan and/or CSF amyloid level). The effect of the T allele on hippocampal volume was present in both amyloid-negative (left column) and amyloid-positive (right column) participants. Upon statistical analysis, rs9608282 is significantly associated with hippocampal volume in amyloid-negative and even amyloid-positive participants (p = 0.027, p =0.015, respectively).