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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Pharm Sci. 2017 Oct 31;107(1):113–120. doi: 10.1016/j.xphs.2017.10.033

Table 1.

pKa values of cocrystal and salt constituents.

Compound Abbreviation pKa
Lamotrigine LTG 5.7a
Saccharin SAC 1.6b
Nicotinamide NCT 3.4c
Phenobarbital PB 7.5d, 11.8e
a

Reference9,10

b

Determined at 25°C in water11

c

Determined at 20°C and 0.01 M ionic strength12

d

Determined at 25°C and 0.02 M ionic strength13

e

Reference9