Table 1.
CSC-induced genes
| GenBank | Symbol | Gene name | Gene function | Average fold change (increase)
|
|||
|---|---|---|---|---|---|---|---|
| NHEK | Leuk1 | Leuk2 | 101A | ||||
| NM 000499 | CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | Electron transport | 30.68 | 15.8 | 12.57 | 15.46 |
| AU144855 | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | Electron transport | 10.19 | 14.56 | 14.76 | 4.56 |
| NM 001353 | AKR1C1 | Aldo-keto reductase family 1, member C1 | Xenobiotic metabolism | 6.54 | 5.95 | 7.69 | 9.66 |
| AB018580 | AKR1C3 | Aldo-keto reductase family 1, member C3 | Xenobiotic metabolism | 10.83 | 7.82 | 9.03 | 18.79 |
| NM 020299 | AKR1B10 | Aldo-keto reductase family 1, member B10 | Aldehyde metabolism | 4.07 | 1.09 | 4.0 | 2.31 |
| AA488687 | SLC7A11 | Solute carrier family 7 | Transport | 4.73 | 2.02 | 4.63 | 2.52 |
| NM 000691 | ALDH3A1 | Aldehyde dehydrogenase 3 family, memberA1 | Aldehyde metabolism | 5.90 | 4.11 | 3.17 | 6.09 |
| NM 003662 | PIR | Pirin | Transcription from POL II promoter | 4.31 | 4.18 | 4.23 | 5.10 |
| BC005352 | TNFAIP8 | Tumor necrosis factor, alpha-induced protein 8 | Anti-apoptosis | 4.15 | 1.67 | 2.18 | 1.64 |
| NM 001107 | ACYP1 | Acylphosphatase 1 | Phosphate metabolism | 3.31 | 1.36 | 1.24 | 1.81 |
| AA918224 | KIAA0092 | Translokin | Fibroblast growth factor binding | 3.33 | 1.38 | 1.13 | 1.29 |
| AF119814 | ZNF291 | Zinc finger protein 291 | Unknown | 2.65 | 1.24 | 2.06 | 3.29 |
| N36997 | YT521 | Splicing factor YT521-B | Unknown | 2.65 | 0.99 | 1.32 | 1.00 |
| NM 000081 | CHS1 | Chediak-Higashi syndrome 1 | Intracellular protein transport | 2.62 | 1.34 | 3.64 | 1.19 |
| NM 004915 | ABCG1 | ATP-binding cassette, subfamily G (WHITE), member 1 | Small molecule transport | 2.30 | 2.61 | 8.45 | 2.12 |
| NM 005689 | ABCB6 | ATP-binding cassette, subfamily B (MDR/TAP), member6 | Oncogenesis | 2.24 | 1.29 | 1.81 | 2.55 |
| NM 002395 | ME1 | Malic enzyme 1, NADP(+)-dependent, cytosolic | Malate metabolism | 2.11 | 2.33 | 2.02 | 2.10 |
| AI689429 | PRKCI | Protein kinase C, iota | Intracellular signaling cascade | 2.01 | 1.51 | 3.32 | 1.71 |
| NM 005864 | EFS | Embryonal Fyn-associated substrate | Intracellular signaling cascade | 1.15 | 1.72 | 1.82 | 3.30 |
| NM 022353 | OSGEPL1 | O-sialoglycoprotein endopeptidase-like 1 | Unknown | 1.95 | 1.31 | 2.02 | 2.22 |
| NM 022496 | ACTR6 | Actin-related protein 6 | Unknown | 1.71 | 1.83 | 1.61 | 2.17 |
| BC006471 | AF1Q | ALL1-fused gene from chromosome 1q | Cell growth | 1.83 | 1.56 | 2.18 | 2.08 |
| NM 016951 | CKLF | Chemokine-like factor | Chemotaxis | 1.38 | 2.03 | 2.86 | 1.31 |
| NM 003930 | SCAP2 | src family associated phosphoprotein 2 | Protein complex assembly | 1.65 | 1.56 | 3.04 | 1.44 |
| NM 015416 | HCCR1 | Cervical cancer 1 protooncogene | Unknown | 1.93 | 1.39 | 2.82 | 1.37 |
| AI760629 | CLCN3 | Chloride channel 3 | Chloride transport | 1.65 | 1.36 | 2.81 | 1.75 |
| AU149908 | UBXD2 | UBX domain containing 2 | Regulation of transcription | 1.96 | 1.77 | 2.03 | 1.79 |
The list includes 27 genes overexpressed (≥2-fold; p < 0.005) in CSC-treated (25 μg/ml, 24 h) vs. untreated cells in any one of the cell lines NHEK, Leuk1, Leuk2 and 101A. Assignments of gene functions to biological processes were extracted using PathwayAssist datamining software. Fold changes are derived from the averages of two independent microarray experiments.