Fig 5. Dexmedetomidine suppresses LPS-induced mRNA expressions of inflammation cytokines, Caspase 3, iNOS and increased Bcl-2 expression in BV-2 cells.

BV2 cells were challenged with PBS (control) or LPS or LPS combined with Dex or Dex+Yoh for 8 h. TNF-α, MCP-1, IDO1, Bcl-2, iNOS and caspase-3 mRNA expression were determined using RT-PCR (left panel) and quantitative real-time PCR (right panel). Data are mean ± SEM. All groups n = 3. * P < 0.05; ** P < 0.005.