Fig 4. Effect of MMV665917 on secondary health measures in C. parvum infected calves.

Overall health, hydration, and appetite were assessed twice daily on days 4–11 after infection using standardized three point scores (1 = normal, 3 = severely abnormal). The area under the curve (AUC) for each metric was determined for each animal’s average daily score plotted vs. time using a baseline score of 1 (normal). Each graph shows a scatter plot of data for individual animals, along with means and 95% confidence intervals (n = 7 for control; n = 6 for MMV665917 treated). p values were determined using the unpaired, single-sided student’s t test. (A) Overall health scores. (B) Hydration scores. (C) Appetite scores.