Table 5.

Change in Waist-Hip Ratio Between Baseline and the Third Examination and Age-Related Macular Degenerationat the Third Examination Stratified by Baseline Weight

			OR (95% CI) of AMD
WHR Change	Participants, No.	Participants at Risk, No.	Adjusted for Age, Sex, Race, and Centera	Multivariate-Adjustedb	Multivariate-Adjustedc
Obese
Decreased	9	414	0.39 (0.20–0.77)	0.38 (0.19–0.77)	0.41 (0.20–0.82)
Stable	137	2649	1 [Reference]	1 [Reference]	1 [Reference]
Increased	9	236	0.83 (0.41–1.65)	0.85 (0.41–1.76)	0.85 (0.41–1.78)
Overweight
Decreased	23	453	0.87 (0.56–1.36)	0.87 (0.55–1.37)	0.83 (0.52–1.34)
Stable	208	4075	1 [Reference]	1 [Reference]	1 [Reference]
Increased	22	489	0.95 (0.60–1.49)	0.94 (0.59–1.51)	0.95 (0.58–1.54)
Normal weight
Decreased	18	373	1.00 (0.60–1.66)	0.92 (0.55–1.54)	0.96 (0.57–1.61)
Stable	147	3212	1 [Reference]	1 [Reference]	1 [Reference]
Increased	31	517	1.42 (0.95–2.12)	1.61 (1.06–2.45)	1.45 (0.93–2.27)

Abbreviations: AMD, age-related macular degeneration; CI, confidence interval; OR, odds ratio; WHR, waist-hip ratio.

^aAdjusted in logistic regression models.

^bAdjusted additionally for baseline WHR.

^cAdjusted additionally for baseline smoking status, years of cigarette smoking, change in smoking status during follow-up, baseline body mass index (calculated as weight in kilograms divided by height in meters squared), systolic blood pressure, prior coronary heart disease, diabetes, total cholesterol level, triglycerides level, serum glucose level, plasma fibrinogen level, white blood cell count, and physical activity level.

^dDecrease and increase in WHR are defined as the bottom and top sex-specific deciles, respectively, of percentage change in WHR over the 6-year follow-up.