TABLE 3.
Capecitabine and metabolites plasma PK parameters [Mean (%CV)] following administration of capecitabine 650mg/m2
| Day | n | Cmax (ng/ml) |
tmax
a (hours) |
n | AUC 0–8h (ng/ml) |
n | t ½ (hours) |
|
|---|---|---|---|---|---|---|---|---|
| Capecitabine | 1 | 15 | 5290 (95) | 0.5 (0.2–1.3) | 10 | 6180 (67) | 10 | 1.8 (97) |
| 14 | 14 | 3030 (64) | 0.7 (0.2–3.5) | 10 | 6340 (72) | 6 | 1.1 (29) | |
| 5’-DFCR | 1 | 15 | 2830 (62) | 0.5 (0.3–1.3) | 10 | 5260 (74) | 10 | 1.6 (67) |
| 14 | 14 | 2450 (57) | 1.0 (0.3–3.5) | 11 | 5120 (54) | 4 | 1.1 (33) | |
| 5’-DFUR | 1 | 15 | 3750 (53) | 0.5 (.3–1.3) | 8 | 5920 (54) | 8 | 1.8 (59) |
| 14 | 14 | 3370 (80) | 1.0 (0.3–3.5) | 8 | 5450 (44) | 2 | 1.3 (48) | |
| 5-FU | 1 | 15 | 122 (114) | 0.9 (0.3–3.0) | 6 | 121 (34) | 5 | 1.7 (59) |
| 14 | 14 | 138 (122) | 0.9 (0.2–3.5) | 9 | 178 (40) | 4 | 1.3 (48) | |
| FBAL | 1 | 15 | 1580 (34) | 2.4 (0.8–6.0) | 11 | 5600 (36) | 3 | 2.3 (42) |
| 14 | 14 | 1900 (37) | 3.0 (0.8–6.0)) | 12 | 6840 (32) | 3 | 1.9 (5.7) |
a
Median (min-max)