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E1 protein complexes with and is recruited to the replication origin by the E2-K111 mutants. (A) C33A cells were cotransfected with PFLORI31, HPV31 HA-E2, and FLAG-E1. ChIP for E1 was conducted with M2 antibody and LCR4 primers. (B) HeLa cells were transfected with HPV31 FLAG-E1 and HA-E2, and the presence of E2 at the HeLa origin was determined by ChIP. *, P < 0.05; **, P < 0.005.
