TABLE 2.
Neutralizing antibody ID50 titers of rhesus sera against the wild-type and mutant clonesa
| Tier | Clone | ID50 titer |
||
|---|---|---|---|---|
| 4 wk postinfection | 40 wk postinfection | 80 wk postinfection | ||
| 1 | wt | 28,900 | 211,000 | 1,360,000 |
| ΔCT | <20 | 65 | 1,540 | |
| 2 | wt | <20 | 380 | 406 |
| ΔCT | <20 | <20 | 1,870 | |
| 3 | wt | <20 | <20 | 568 |
| ΔCT | <20 | <20 | 4,920 | |
a
ID50 titers were calculated with nonlinear regression by using PRISM5 and are expressed as the highest dilution of sera that resulted in a 50% reduction of RLU compared with the virus control. The sera used were collected at 4 weeks, 40 weeks, and 80 weeks postinfection from a rhesus macaque infected with the SIVsmE660 tier 1 virus. wt, wild type.