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. 2018 Jan 17;92(3):e01773-17. doi: 10.1128/JVI.01773-17

TABLE 2.

Overview of PB1 mutant characteristics relative to the wild typea

Enzyme RNP reconstitution
Extension on vRNA Extension on cRNA
RNA cleavage Trimer formation
vRNA mRNA FL FR
Wild type +++ +++ +++ +++ +++ +++ +++
S269A + + +++ +++ +++ NT +++
L271A NT NT NT +++ +++ NT +++
P272A NT NT NT NT +++
V273A + +++ +++ ++++ NT +++
Δ648–651 ++++ ++++ ++++ +++ +++
Δ631–662 +
Δ642–656 ++++ + ++++ +++ +++
Δ656–662 +++
Δ631–642 + +++ + +++
Δ636–642 +++ ++ ++++ +++ +++
Δ631–635 + + + +++
a

++++, >100% of the value for the wild type; +++, 75 to 100% of the value for the wild type; ++, 50 to 75% of the value for the wild type; +, 25 to 50% of the value for the wild type; −, 0 to 25% of the value for the wild type; NT, not tested.