TABLE 1.

Defnition of dose-limiting events based on local skin responses

TREATMENT AREA	LOCAL SKIN RESPONSES
Face/chest	At least one of the following LSRs: crusting Grade 4, erosion/ulceration Grade 4, vesiculation/postulation Grade 4; or at least two of the following LSRs: erythema Grade 4, crusting Grade 3, swelling Grade 4, erosion/ulceration Grade 3, vesiculation/postulation Grade 3
Scalp	Erosion/ulceration Grade 4
Trunk/extremities	At least one of the following LSRs: crusting Grade 4, erosion/ulceration Grade 4, vesiculation/postulation Grade 4; or at least two of the following LSRs: crusting Grade 3, swelling Grade 4, erosion/ulceration Grade 3, vesiculation/postulation Grade 3

LSR: local skin response