TABLE 1.
Subject instrumental hair measurements and calculations
| VARIABLE | ENDPOINT | MFSO® (N = 24) | VEHICLE (N =17) | ARGAN OIL BRAND (N = 16) | P-VALUE* |
|---|---|---|---|---|---|
| Diameter (μm) | Baseline mean (SD) | 54.9 (6.34) | 57.1 (8.22) | 55.8 (9.39) | NT |
| Month 4 mean (SD) | 54.0 (7.93) | 57.0 (7.09) | 55.2 (8.16) | NT | |
| percent improvement from baseline at Month 4 mean (SD) p-value** | -1.5 (9.22) | 0.4 (7.39) NT |
-0.4 (7.89) NT |
0.778 | |
| Month 8 mean (SD) | 55.4 (7.94) | 56.5 (7.55) | 55.4 (8.38) | NT | |
| percent improvement from baseline at Month 8 mean (SD) p-value | 0.8 (7.71) | -0.7 (7.26) NT |
-0.3 (5.45) NT |
0.773 | |
| HBI50 (%) | Baseline mean (SD) | 28.9 (7.10) | 24.6 (7.09) | 23.9 (7.25) | NT |
| Month 4 mean (SD) | 13.5 (4.27) | 20.1 (7.79) | 19.3 (6.31) | NT | |
| percent improvement from baseline at Month 4 mean (SD) p-value** | 50.6 (18.64) | 17.7 (20.67) <0.001 |
17.4 (21.78) <0.001 |
<0.001 | |
| Month 8 mean (SD) | 10.9 (3.97) | 18.9 (8.35) | 17.7 (6.48) | NT | |
| percent improvement from baseline at Month 8 mean (SD) p-value | 60.2 (16.60) | 23.1 (24.94) <0.001 |
24.2 (27.54) <0.001 |
<0.001 | |
| HBI75 (%) | Baseline mean (SD) | 52.5 (8.56) | 45.8 (10.61) | 43.1 (10.69) | NT |
| Month 4 mean (SD) | 27.7 (9.24) | 35.6 (9.80) | 31.4 (11.82) | NT | |
| percent improvement from baseline at Month 4 mean (SD) p-value** | 47.0 (15.42) | 22.1 (11.37) <0.001 |
26.6 (23.20) <0.001 |
<0.001 | |
| Month 8 mean (SD) | 19.3 (10.50) | 32.0 (9.20) | 29.1 (13.10) | NT | |
| percent improvement from baseline at Month 8 mean (SD) p-value | 63.2 (18.62) | 30.0 (10.60) <0.001 |
31.6 (29.41) <0.001 |
<0.001 | |
| HHI50 (%-1) | Baseline mean (SD) | 3.7 (0.92) | 4.4 (1.31) | 4.6 (1.46) | NT |
| Month 4 mean (SD) | 8.1 (2.46) | 5.7 (2.13) | 5.8 (2.03) | NT | |
| percent improvement from baseline at Month 4 mean (SD) p-value** | 133.7 (93.88) | 32.1 (46.34) <0.001 |
29.5 (35.87) <0.001 |
<0.001 | |
| Month 8 mean (SD) | 10.2 (3.20) | 6.4 (2.83) | 6.5 (2.91) | NT | |
| percent improvement from baseline at Month 8 mean (SD) p-value | 188.3 (103.69) | 45.7 (55.52) <0.001 |
44.7 (39.66) <0.001 |
<0.001 | |
| HHI75 (%-1) | Baseline mean (SD) | 2.0 (0.31) | 2.3 (0.59) | 2.5 (0.58) | NT |
| Month 4 mean (SD) | 4.0 (1.19) | 3.0 (0.77) | 3.6 (1.29) | NT | |
| percent improvement from baseline at Month 4 mean (SD) p-value** | 103.6 (55.34) | 30.8 (17.92) <0.001 |
47.6 (40.36) <0.001 |
<0.001 | |
| Month 8 mean (SD) | 6.1 (2.01) | 3.3 (0.89) | 4.0 (1.53) | NT | |
| percent improvement from baseline at Month 8 mean (SD) p-value | 215.7 (102.25) | 45.8 (20.61) <0.001 |
64.4 (48.30) <0.001 |
<0.001 |
MFSO®: Miracle Fruit Seed Oil; n: number; SD: standard deviation; NT: not tested; HBI: Hair Breakage Index; HHI: Healthy Hair Index;
*
=p-value is from an ANOVA F-test test of the null hypothesis of no difference among the three treatment groups
**
=p-value is from an ANOVA based t-test between the MFSO and the given treatment group