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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Trends Endocrinol Metab. 2017 Nov 8;28(12):868–878. doi: 10.1016/j.tem.2017.10.007

Table 2.

Recent studies assessing hepatic expression of MAPKs in obese humans

MAPK Metabolic disorder/disease Hepatic MAPK expression in obesity and NASH/NAFLD References
JNK1/2 Liver samples from patients with steatosis and NASH No difference in hepatic JNK phosphorylation in NASH patients [56]
JNK1 Liver biopsies from obese patients with NASH Elevated hepatic JNK phosphorylation in obese NASH patients [57]
JNK1/2 Liver biopsies from obese patients with hepatic steatosis/NASH Increased hepatic JNK phosphorylation in obese NASH patients [58]
p38δ MAPK Liver biopsies from obese patients with hepatic steatosis/NAFLD Increased hepatic expression of p38δ in obese patients with NAFLD [44]