4.

Univariate and multivariate analysis for factors predictive of OS (N=1,335)

Prognostic factors	Univariate				Multivariate
	HR	95% CI	P		HR	95% CI	P
OS, overall survival; BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; AC, adenocarcinoma; ASC, adenosquamous carcinoma; LNM, lymph node metastasis; LVSI, lymphovascular space invasion; HR, hazard ratio; 95% CI, 95% confidence interval.
Age at diagnosis (year) (≥45 vs. <45)	1.034	0.576–1.854	0.912		–	–	–
BMI (kg/m2) (≥24 vs. <24)	0.949	0.528–1.705	0.861		–	–	–
FIGO stage (Ib vs. IIa)	1.057	0.509–2.195	0.882		–	–	–
Tumor size (cm) (≤4 vs.>4)	0.890	0.490–1.618	0.703		–	–	–
Histology (SCC vs.AC vs. ASC)	1.165	0.460–2.952	0.747		–	–	–
Differentiation (G1–G2 vs. G3)	0.317	0.169–0.596	0.000		0.469	0.245–0.896	0.022
LNM (+ vs. –)	7.809	4.300–14.181	0.000		5.117	2.725–9.610	0.000
Stromal invasion (≥1/2 vs. <1/2)	1.760	0.969–3.199	0.060		–	–	–
LVSI (+ vs. –)	5.622	3.111–10.162	0.000		3.054	1.620–5.755	0.001