3.
Performance of physician- and self-collected careHPV in age-specific primary screening, stratified by RLU/CO cutoffs, for CIN2+ detection among 2,337 women, compared to physician-HC2 testing
| Age (year) | Primary screening | Positivity cutoff (RLU/CO) | % (95% CI) | Colposcopy per CIN2+ (N) | ||||
| Referral rate | Sensitivity | Specificity | PPV | NPV | ||||
| 30 to 54 | Physician-
careHPV |
1.00 | 14.0
(12.7–15.5) |
83.8
(73.3–90.7) |
88.1
(86.7–89.3) |
17.4
(13.7–21.9) |
99.5
(99.0–99.7) |
5.8 |
| 2.00 | 11.8
(10.5–13.1) |
80.9
(70.0–88.5) |
90.3
(89.0–91.5) |
20.0
(15.7–25.1) |
99.4
(98.9–99.6) |
5.0 | ||
| 5.00 | 10.1
(8.9–11.3) |
76.5
(65.1–85.0) |
91.9
(90.7–93.0) |
22.1
(17.3–27.9) |
99.2
(98.8–99.5) |
4.5 | ||
| 10.00 | 8.4
(7.3–9.6) |
72.1
(60.4–81.3) |
93.5
(92.4–94.5) |
25.0
(19.5–31.5) |
99.1
(98.6–99.4) |
4.0 | ||
| Self-careHPV | 1.00 | 13.6
(12.2–15.0) |
72.1
(60.4–81.3) |
88.2
(86.8–89.5) |
15.5
(11.9–19.8) |
99.1
(98.5–99.4) |
6.5 | |
| 2.00 | 10.9
(9.7–12.2) |
63.2
(51.4–73.7) |
90.7
(89.4–91.8) |
16.9
(12.8–22.0) |
98.8
(98.2–99.2) |
5.9 | ||
| 5.00 | 8.3
(7.3–9.5) |
47.1
(35.7–58.8) |
92.8
(91.7–93.8) |
16.4
(11.9–22.2) |
98.3
(97.7–98.8) |
6.1 | ||
| 10.00 | 6.5
(5.5–7.5) |
32.4
(22.4–44.2) |
94.3
(93.3–95.2) |
14.6
(9.8–21.1) |
97.9
(97.2–98.4) |
6.9 | ||
| Physician-HC2 | 1.00 | 16.4
(15.0–18.0) |
97.1
(89.9–99.2) |
86.0
(84.5–87.4) |
17.2
(13.7–21.3) |
99.9
(99.6–100) |
5.8 | |
| 2.00 | 14.3
(12.9–15.8) |
95.6
(87.8–98.5) |
88.1
(86.8–89.4) |
19.5
(15.6–24.0) |
99.9
(99.6–100) |
5.1 | ||
| 5.00 | 12.7
(11.4–14.1) |
91.2
(82.1–95.9) |
89.6
(88.3–90.8) |
20.9
(16.6–25.9) |
99.7
(99.4–99.9) |
4.8 | ||
| 10.00 | 11.5
(10.3–12.9) |
86.8
(76.7–92.9) |
90.7
(89.5–91.9) |
21.9
(17.4–27.3) |
99.6
(99.2–99.8) |
4.6 | ||
| 30 to 44 | Physician-
careHPV |
1.00 | 12.1
(10.4–13.9) |
84.6
(70.3–92.8) |
90.1
(88.3–91.6) |
20.2
(14.8–27.1) |
99.5
(98.9–99.8) |
4.9 |
| 2.00 | 10.3
(8.8–12.0) |
84.6
(70.3–92.8) |
91.9
(90.3–93.3) |
23.7
(17.4–31.5) |
99.5
(98.9–99.8) |
4.2 | ||
| 5.00 | 8.7
(7.3–10.3) |
76.9
(61.7–87.4) |
93.4
(91.9–94.6) |
25.6
(18.6–34.2) |
99.3
(98.6–99.6) |
3.9 | ||
| 10.00 | 7.6
(6.3–9.1) |
74.4
(58.9–85.4) |
94.4
(93.1–95.5) |
28.4
(20.6–37.8) |
99.2
(98.5–99.6) |
3.5 | ||
| Self-careHPV | 1.00 | 12.7
(11.0–14.6) |
79.5
(64.5–89.2) |
89.3
(87.5–90.9) |
18.1
(13.1–24.6) |
99.3
(98.7–99.7) |
5.5 | |
| 2.00 | 9.9
(8.4–11.6) |
64.1
(48.4–77.3) |
91.8
(90.1–93.1) |
18.8
(13.1–26.3) |
98.8
(98.1–99.3) |
5.3 | ||
| 5.00 | 8.1
(6.8–9.7) |
48.7
(33.9–63.8) |
93.1
(91.6–94.3) |
17.3
(11.3–25.4) |
98.4
(97.5–99.0) |
5.8 | ||
| 10.00 | 6.1
(5.0–7.6) |
28.2
(16.5–43.8) |
94.5
(93.1– 95.6 ) |
13.3
(7.6–22.2 ) |
97.8
(96.8–98.5) |
7.5 | ||
| Physician-HC2 | 1.00 | 14.6
(12.8–16.6) |
97.4
(86.8–99.5) |
87.9
(86.0–89.5) |
19.3
(14.4–25.4) |
99.9
(99.5–100) |
5.2 | |
| 2.00 | 12.7
(11.1–14.6) |
94.9
(83.1–98.6) |
89.7
(87.9–91.2) |
21.5
(16.0–28.2) |
99.8
(99.4–100) |
4.6 | ||
| 5.00 | 11.1
(9.5–12.9) |
92.3
(79.7–97.3) |
91.3
(89.7–92.7) |
24.0
(17.9–31.4) |
99.8
(99.3–99.9) |
4.2 | ||
| 10.00 | 10.0
(8.5–11.7) |
89.7
(76.4–95.9) |
92.4
(90.8–93.7) |
25.9
(19.3–33.9) |
99.7
(99.2–99.9) |
3.9 | ||
| Table 3 (continued ) | ||||||||