4.
Performance of physician- and self-collected careHPV in age-specific primary screening, stratified by RLU/CO cutoffs, for CIN3+ detection among 2,337 women, compared to physician-HC2 testing
| Age (year) | Primary screening | Positivity cutoff (RLU/CO) | % (95% CI) | Colposcopy per CIN3+ (N) | ||||
| Referral rate | Sensitivity | Specificity | PPV | NPV | ||||
| 30 to 54 | Physician-
careHPV |
1.00 | 14.0
(12.7–15.5) |
87.0
(67.9–95.5) |
86.7
(85.2–88.0) |
6.1
(4.0–9.2) |
99.9
(99.6–99.9) |
16.4 |
| 2.00 | 11.8
(10.5–13.1) |
87.0
(67.9–95.5) |
89.0
(87.6–90.2) |
7.3
(4.8–11.0) |
99.9
(99.6–100) |
13.8 | ||
| 5.00 | 10.1
(8.9–11.3) |
82.6
(62.9–93.0) |
90.7
(89.4–91.8) |
8.1
(5.2–12.3) |
99.8
(99.5–100) |
12.4 | ||
| 10.00 | 8.4
(7.3–9.6) |
78.3
(58.1–90.3) |
92.3
(91.2–93.3) |
9.2
(5.9–14.0) |
99.8
(99.5–99.9) |
10.9 | ||
| Self-careHPV | 1.00 | 13.6
(12.2–15.0) |
78.3
(58.1–90.3) |
87.1
(85.7–88.4) |
5.7
(3.6–8.8) |
99.8
(99.4–99.9) |
17.6 | |
| 2.00 | 10.9
(9.7–12.2) |
69.6
(49.1–84.4) |
89.7
(88.4–90.9) |
6.3
(3.9–10.0) |
99.7
(99.3–99.8) |
15.9 | ||
| 5.00 | 8.3
(7.3–9.5) |
56.5
(36.8–74.4) |
92.1
(91.0–93.2) |
6.7
(4.2–11.8) |
99.5
(99.1–99.7) |
15.0 | ||
| 10.00 | 6.5
(5.5–7.5) |
39.1
(22.2–59.2) |
93.9
(92.8–94.8) |
6.0
(3.2–10.9) |
99.4
(98.9–99.6) |
16.8 | ||
| Physician-HC2 | 1.00 | 16.4
(15.0–18.0) |
95.7
(79.0–99.2) |
84.4
(82.8–85.8) |
5.7
(3.8–8.5) |
99.9
(99.7–100) |
17.5 | |
| 2.00 | 14.3
(12.9–15.8) |
95.7
(79.0–99.2) |
86.5
(85.1–87.9) |
6.6
(4.4–9.8) |
100
(99.7–100) |
15.2 | ||
| 5.00 | 12.7
(11.4–14.1) |
95.7
(79.0–99.2) |
88.1
(86.7–89.4) |
7.4
(4.9–11.0) |
100
(99.7–100) |
13.5 | ||
| 10.00 | 11.5
(10.3–12.9) |
91.3
(73.2–97.6) |
89.3
(88.0–90.5) |
7.8
(5.2–11.6) |
99.9
(99.6–100) |
12.8 | ||
| 30 to 44 | Physician-
careHPV |
1.00 | 12.1
(10.4–13.9) |
91.67
(64.6–98.6) |
88.6
(86.8–90.2) |
6.8
(3.8–11.7) |
99.9
(99.5–100) |
14.8 |
| 2.00 | 10.3
(8.8–12.0) |
91.67
(64.6–98.5) |
90.4
(88.7–91.9) |
7.9
(4.5–13.6) |
99.9
(99.5–100) |
12.6 | ||
| 5.00 | 8.7
(7.3–10.3) |
83.33
(55.2–95.3) |
92.0
(90.4–93.3) |
8.6
(4.7–15.0) |
99.8
(99.4–100) |
11.7 | ||
| 10.00 | 7.6
(6.3–9.1) |
83.33
(55.2–95.3) |
93.1
(91.6–94.4) |
9.8
(5.4–17.1) |
99.8
(99.4–100) |
10.2 | ||
| Self-careHPV | 1.00 | 12.7
(11.0–14.6) |
91.7
(64.6–98.5) |
88.0
(86.2–89.7) |
6.4
(3.6–11.1) |
99.9
(99.5–100) |
15.5 | |
| 2.00 | 9.9
(8.4–11.6) |
75.0
(46.8–91.1) |
90.7
(89.1–92.2) |
6.8
(3.6–12.4) |
99.8
(99.3–100) |
14.8 | ||
| 5.00 | 8.1
(6.8–9.7) |
58.3
(32.0–80.7) |
92.3
(90.7–93.6) |
6.4
(3.1–12.6) |
99.6
(99.1–99.8) |
15.7 | ||
| 10.00 | 6.1
(5.0–7.6) |
33.3
(13.8–60.9) |
94.1
(92.7–95.2) |
4.8
(1.9–11.7) |
99.4
(98.8–99.7) |
20.8 | ||
| Physician-HC2 | 1.00 | 14.6
(12.8–16.6) |
91.7
(64.6–98.5) |
86.1
(84.1–87.8) |
5.6
(3.1–9.7) |
99.9
(99.5–100) |
17.9 | |
| 2.00 | 12.7
(11.1–14.6) |
91.7
(64.6–98.5) |
88.0
(86.1–89.6) |
6.4
(3.6–11.1) |
99.9
(99.5–100) |
15.6 | ||
| 5.00 | 11.1
(9.5–12.9) |
91.7
(64.6–98.5) |
89.6
(87.9–91.1) |
7.3
(4.1–12.7) |
99.9
(99.5–100) |
13.6 | ||
| 10.00 | 10.0
(8.5–11.7) |
91.7
(64.6–98.5) |
90.7
(89.1–92.2) |
8.2
(4.6–14.0) |
99.9
(99.5–100) |
12.3 | ||
| Table 4 (continued ) | ||||||||