S2.
Clinical performance of physician- and self-collected careHPV testing in primary and triage screening strategies, stratified by age, for CIN3+ detection among 2,337 women
| Primary screening | Triage strategy | Age (year) | CIN3+ (N=23) | % (95% CI) | Colposcopy per CIN3+ (N) | ||||
| Sensitivity | Specificity | PPV | NPV | Youden’s index | |||||
| HPV, human papillomavirus; CIN3+, cervical intraepithelial neoplasia grade 3 or worse; RLU/CO, relative light units/cutoff; HC2, Hybrid Capture 2; ASC-US+, atypical squamous cells of undetermined significance or worse; VIA, visual inspection with acetic acid; 95% CI, 95% confidence interval; PPV, positive predictive value; NPV, negative predictive value. | |||||||||
| Physician-careHPV ≥1.0 RLU/CO | ASC-US+ | 30 to 44 | 10 | 83.3
(55.2–95.3) |
94.5
(93.2–95.6) |
12.0
(6.7–20.8) |
99.8
(99.4–100) |
77.9 | 8.3 |
| 45 to 54 | 9 | 81.8
(52.3–94.9) |
92.1
(90.2–93.6) |
10.5
(5.6–18.7) |
99.8
(99.2–99.9) |
73.9 | 9.6 | ||
| VIA | 30 to 44 | 7 | 58.3
(32.0–80.7) |
98.6
(97.8–99.1) |
26.9
(13.7–46.1) |
99.6
(99.1–99.8) |
56.9 | 3.7 | |
| 45 to 54 | 5 | 45.5
(28.0–78.7) |
99.1
(98.3–99.5) |
35.7
(16.3–61.2) |
99.4
(98.7–99.7) |
44.5 | 2.8 | ||
| Self-careHPV ≥1.0 RLU/CO | ASC-US+ | 30 to 44 | 9 | 75.0
(46.8–91.1) |
95.4
(94.2–96.4) |
12.9
(6.9–22.7) |
99.8
(99.3–99.9) |
70.4 | 7.8 |
| 45 to 54 | 7 | 63.6
(35.4–84.8) |
94.9
(93.3–96.1) |
12.3
(6.1–23.2) |
99.6
(98.9–99.8) |
58.5 | 8.1 | ||
| VIA | 30 to 44 | 7 | 58.3
(32.0–80.7) |
98.6
(97.8–99.1) |
26.9
(13.7–46.1) |
99.6
(99.1–99.8) |
56.9 | 3.7 | |
| 45 to 54 | 3 | 27.3 (9.7–56.6) | 99.3 (98.4–99.6) | 30.0 (10.8–60.3) | 99.2 (98.4–99.6) | 26.6 | 3.3 | ||
| Physician-HC2 ≥1.0 RLU/CO | ASC-US+ | 30 to 44 | 10 | 83.3
(55.2–95.3) |
93.3
(91.8–94.5) |
10.0
(5.5–17.4) |
99.8
(99.6–100) |
76.6 | 10.0 |
| 45 to 54 | 11 | 100
(74.1–100) |
91.8
(89.9–93.4) |
12.1
(6.9–20.4) |
100
(99.4–100) |
91.8 | 8.3 | ||
| VIA | 30 to 44 | 7 | 58.3
(32.0–80.7) |
98.2
(97.3–98.8) |
22.6
(11.4–39.8) |
99.6
(99.1–99.8) |
56.5 | 4.4 | |
| 45 to 54 | 6 | 54.5
(28.0–78.7) |
98.9
(98.0–99.4) |
35.3
(17.3–58.7) |
99.5
(98.0–99.4) |
53.4 | 2.8 | ||