Figure 5. Assessment of LV systolic function.
A. Representative M-mode images from vehicle-treated, iPSC-treated, and iPSC-EV-treated mice at 35 d after coronary occlusion/reperfusion. Compared with the vehicle-treated heart, both iPSC-treated and iPSC-EV-treated hearts exhibit improved wall motion, smaller LV cavity (D,E), and thicker infarct wall (F). Transplantation of iPSC-EVs resulted in greater improvement in LV systolic function (B,C). Data are mean ± SEM. n=7–12 mice per group. *P<0.05 vs. Vehicle at 35 d; #P<0.05 vs. iPSC group at 35 d. BSL, baseline; d, days; LV, left ventricular.