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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Hepatol. 2017 Nov 9;68(2):230–237. doi: 10.1016/j.jhep.2017.10.031

Fig. 1.

Fig. 1

The key features of human NAFLD and representative histological features in a mouse model of NAFLD (DIAMOND). Predominantly macro-vesicular steatosis in steatohepatitis (left panel 10x) after 16 weeks of a high fat diet (Harlan Teklad # TD 88137) with ad libitum administration 23.1g/L d-fructose and n18.9 g/L d-glucose) in the DIAMOND mice. The pattern is similar to that seen in humans with NASH (Panels A and B (right panel 10x)). Similarly, Panels C and D demonstrate hepatocellular ballooning in mice and in humans respectively. Panels E and F demonstrate lobular inflammation in mice and in humans. These provide proof of concept that the features of human NASH can be recapitulated in humans (adapted from asgharpour et al., 7).